Terry Young, PhD

Professor

Email: tbyoung@wisc.edu

Biography:

Terry Young, PhD, is an epidemiologist with a specialty in sleep disorders. Dr. Young’s research focus is on the natural history of sleep apnea and other sleep disorders. Of particular interest: the role of sleep apnea in cardiovascular and behavioral morbidity, development of sleep disorders with aging, genetic markers for sleep disorders, sleep disorders over the menopausal transition. This research is based on overnight in-laboratory sleep studies and other protocols conducted every four years on a large population-based cohort of men and women: the Wisconsin Sleep Cohort. This unique, NIH funded, ongoing cohort study, initiated by Dr. Young over 20 years ago, uncovered the high prevalence of unrecognized sleep apnea in adults Her studies shown unrecognized sleep apnea in the general population to be associated with elevated blood pressure and other blood pressure abnormalities, motor vehicle accidents, quality of life, and increased mortality. Current work includes analyses of the longitudinal data being continuously collected to investigate changes in sleep apnea progression over time, the causal role of sleep apnea and other sleep disorders in health outcomes, and the development of sleep disorders in women over the midlife age span and menopausal transition. Other sleep disorders of interest include narcolepsy and chronic insomnia. Dr. Young also collaborates with molecular geneticists who identified the first human sleep gene (Clock), a gene that may influence circadian patterns . She has been a member of several task forces on sleep disorder nosology (including ICSD9 and ongoing revision for the DSM V). She is on the Executive Board of the UW Center for Sleep Research /WisconsinSleep.

Affiliations/Associations:

• Associate editor, Sleep
• Editorial board, Sleep Medicine Reviews and Sleep Research Online
• Divisional Head (epidemiology), World Health Organization; worldwide project of sleep disorders
• Program Committee, American Academy of Sleep Medicine
• Program Committee, American Thoracic Society
• International Task Force, Sleep-Disordered Breathing Syndrome Definitions and Measurement Techniques in Clinical Research
• University of Wisconsin, Faculty development and award committee
• Department of Population Health Sciences, Steering Committee and Curriculum Committee for Population Health Program

Recent Honors/Awards:

• American Academy of Sleep Medicine 2008 William B Dement Academic Achievement Award

Select Publications:

Young TB, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. Occurrence of sleep disordered breathing among middle-aged adults. New Eng J Med 1993; 328:69-77.

Nieto J, Young T, Lind B et al. Association of sleep-disordered breathing, sleep apnea and hypertension in a large community based study. Sleep Heart Health Study. JAMA 2000; 283:1829-1836.

Peppard P, Young T, Palta M, Skatrud J. Prospective study of the association of sleep disordered breathing and hypertension. N Engl J Med 2000; 342:1378-1384.

Peppard P, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep disordered Breathing. JAMA 2000; 284: 3015-3021.

Morrell MJ, Finn L, Kim H, Peppard P, Badr S, Young T. Sleep fragmentation, awake blood pressure, and sleep-disordered-breathing in a population-based study. Am J Respir Crit Care Med 2000; 162: 2091-2096.

Young T, Shahar E, Nieto F J, et al. Predictors of sleep-disordered breathing in community dwelling adults: The Sleep Heart Health Study. Arch Int Med 2002; 162:893-900.

Young T, Peppard P , Gottleib D. State of the Art Review: Epidemiology of obstructive sleep apnea: a population perspective. Am J Respir Crit Care Med 2002; 165:1217-1739.

Hla KM, Skatrud J, Finn L, Palta M, Young T. The effect of correction of sleep-disordered breathing on blood pressure in untreated hypertension. Chest 2002; 122:1125-32.

Young T, Finn L, Austin D, Peterson A. Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Crit Care Respir Med 2003;167:1181-1185

Shahar E, Redline S, Young T et al. Hormone-replacement therapy and sleep-disordered breathing. Am J Crit Care Respir Med 2003;167:1186-1192.

Young T, Robago D, Zgierska A, Austin D, Finn L. Objective and subjective sleep quality in premenopausal, perimenopausal and postmenopausal women in the Wisconsin Sleep Cohort Study. Sleep 2003;26:667-672.

Gottlieb D, DeStefano AL, Foley DJ, Mignot E, Redline S, Givelber RJ, Young T. APOE 4 is associated with obstructive sleep apnea: The Sleep Heart Health Study. Neurology. 200424;63(4):664-8.

Young T, Peppard P, Skatrud J. Risk factors for obstructive sleep apnea in adults. JAMA 2004.291:2013-2016, 2004
Taheri S , Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced Leptin and elevated Ghrelin and increased body mass index. PloS Med, 2004: 1(3), 210-217.

Lin L, Finn L, Zhang J, Young T, Mignot E. Angiotensin-converting enzyme, sleep-disordered breathing and hypertension. Am J Respir Crit Car Med, 2004: 170, 1349-1353.

Kim H, Young T. Subjective daytime sleepiness: dimensions and correlates in the general population Sleep 2005; 28(5)625-634.

Hass D, Foster G, Nieto J, Redline S, Robbins J, Young T , Age-dependent associations between sleepdisordered breathing and hypertension: the importance of discriminating between systolic/diastolic hypertension in isolated systolic hypertension in the Sleep Heart Health Study. Circulation 2005;111(5):614-621.

Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005 172(11):1447-51.

Newman AB, Foster G, Givelber R, Nieto FJ, Redline S, Young T. Progression and regression of sleep-disordered breathing with changes in weight: the sleep heart health study. Arch Intern Med. 2005;165(20):2408-13.

Reichmuth KJ, Austin D, Skatrud JB, Young T. Association of Sleep Apnea and Type II Diabetes: A Population-based Study. Am J Respir Crit Care Med. 2005 172(12):1590-5.

Mignot E, Lin L, Finn L, Lopes C, Pluff K, Sundstrom ML, Young T. Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain. 2006 ;129(6)1609-23

Arzt M, Young T. Finn L et al. Sleepiness and sleep apnea in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med 2006;166 (16):1716-22.

Peppard P, Szklo M, Hla K, Young T. Longitudinal association of sleep-related breathing disorder and depression. Arch Intern Med. 2006;166(16):1709-15.

Kohatsu ND, Tsai R, Young T et al. Sleep duration and body mass index in a rural population. Arch Intern Med. 2006;166(16):1701-5

Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome in the Wisconsin Sleep Cohort. Sleep Med 2006; 7(7):545-52.

Szklo-Coxe M, Young T, Finn L, Mignot E. Depression: relationships to sleep paralysis and other sleep disturbances in a community sample. J Sleep Res. 2007; 16(3):297-312.

Punjabi NM, Newman AB, Young TB, Resnick HE, Sanders MH.Sleep-disordered breathing and cardiovascular disease: an outcome-based definition of hypopneas. Am J Respir Crit Care Med. 2008 May15;177(10):1150-5.

Hla KM, Young T, Finn L, Peppard P, SZklo M, Stubbs. Longitudinal association of sleep-disordered breathing and non-cipping of nocturnal blood pressue in the Wisconsin Sleep Cohort Study. Sleep 2008; 31(6):795-800.

Somers VK, White DP, Amin R,…Young T et al. Sleep apnea and cardiovascular Disease: American Heart Association Scientific Statement. Circulation 2008;118(1), 1080-11.

Young T, Finn L, Peppard P, Szklo-Coxe M, Austin D, Nieto FJ, Stubbs M, Hla KM. Sleep-disordered breathing and mortality: Eighteen-year follow-up of the Wisconsin Sleep Cohort. SLEEP 2008. 31(8),1071-8.

Courses Taught:

• PHS 375 Introduction to Population Health Sciences

Contact Details: