Lorraine F. Meisner, Ph.D.

 

Lorraine Meisner received her Ph.D. in Genetics from the University of Chicago in 1966.  She has been a faculty member at the University of Wisconsin-Madison since 1968. Dr. Meisner's research centers around identification of genetic changes associated with neoplastic development, and evaluation of their significance.  This specifically involves linking epidemiologic data to specific alterations identified by fluorescent in-situ hybridization (FISH) to identify and quantify genetic changes associated with malignant transformation.  She is also involved in research to evaluate the causes and frequency of cytogenetic aberrations associated with abnormal somatic development resulting in birth defects. Representative Publications: Zilmer M, Harris C, Steiner D, and Meisner L. Use of nonbreakpoint DNA probes to detect the t(X;18) in interphase cells from synovial sarcoma. Implications for detection of diagnostic tumor translocations. Am. J. Pathology 152:1171-1177, 1998. (Monica Zilmer was a med student from Sweden who came to work with me for one year.) Doyle G, Bourdeau-Heller J, Coulthard S, Meisner L, and Ross J. Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. Cancer Research 60: 2756-2759, 2000. Billings, S.D., Meisner, L.F., Cummings, O.W. and Tejada, E. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Modern Pathology, 2000, 13:68-76. Doyle, G.A., Bourdeau-Heller, J.M., Coulthard, S., Meisner, L.F., and Ross, J. Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. Cancer Research, 2000, 60:2756-2759. Allen-Hoffmann, B.L., Schlosser, S.J., Ivarie, C.A., Sattler, C.A., Meisner, L.M. and O’Connor, S.L. Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J. Invest. Dermatol., 2000, 114:444-455. Zilmer M, Harris C, Steiner S, and Meisner L.  Use of non-specific DNA probes to detect diagnostic translocations demonstrated by the t(X;18) in synovial sarcoma.  Am. J. Pathology, 152:1171-1177, 1998. Jacoby RF, Schlack S, Cole CE, Skarbek M, Harris C, and Meisner LF.  A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria.  Gastroenterology, 112:1398-1403, 1997. Logrono R, Garcia-Lithgow C, Harris C, Kent and Meisner L.  Heteropagus conjoined twins due to fusion of two embryos: report and review.  Am. J. Medical Genetics, 73:239-243, 1997. Xing W, Gilchrist K, Harris CP, Samson W, and Meisner LF.  FISH detection of HER-2/neu oncogene amplifications in early onset breast cancer.  Breast Cancer Research and Treatment, 39:203-212, 1996. Contact Information: Lorraine F. Meisner, Ph.D. State Lab of Hygiene University of Wisconsin Medical School Stovall Building, Room 415 465 Henry Mall Madison, Wisconsin 53706-1578 USA Phone: (608) 263-9240 Fax: (608) 265-7818 Email: lorraine@slh.wisc.edu