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Dr. Bautista's research interests includes the distribution of cardiovascular
diseases and risk factors in developing countries, the etiology of coronary
heart disease, and the role of chronic mild inflammation and endothelial
function on blood pressure. His current research focuses on the effect of
C-reactive protein, TNF-alpha, and IL-6 on the development and clinical course
of essential hypertension.
Affiliations/Associations:
Board of Editors, Internet Journal of Epidemiology
Adjunct Professor, Department of Public Health and Preventive Medicine,
Universidad Industrial de Santander, Bucaramanga, Colombia.
Recent Honors/Awards:
Outstanding Educator Award, in recognition of teaching excellence. MPH Class of
2002. Department of Preventive Medicine & Biometrics, Uniformed Services
University of the Health Sciences, June 2002.
Colombian National Academy of Medicine, XII Aventis Award 2001, Best Research
Proposal, “Inflammatory, autonomic, and endothelial markers of survival among
patients with a first acute myocardial infarction”
Regional Anesthesia National Research Award, Colombian Society of
Anesthesiology, 2001, Timing of crystalloid administration and incidence of
cardiovascular side effects during spinal anesthesia: Results from a randomized
controlled trial.
Selected Publications:
- Casas
JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries S, Hingorani A. Endothelial
Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE
Review. Am J Epidemiol 2006, 164(10):921-935.
-
Bautista LE, Oróstegui M, Vera LM, Prada GE, Orozco LC, Herrán
OE. Prevalence and impact of
cardiovascular risk factors in Bucaramanga,
Colombia: results from the
Countrywide Integrated Noncommunicable Disease Intervention Programme (CINDI/CARMEN)
baseline survey. Eur J Cardiovasc Prev Rehabil 2006, 13(5):769-775.
- Bautista LE,
Smeeth L, Hingorani AD, Casas JP. Estimation of bias in non-genetic
observational studies using “Mendelian Triangulation”. Ann Epidemiol 2006,
16(9):675-680.
- Casas JP, Shah T, Cooper J, Hawe E,
McMahon AD, Gaffney D, Packard CJ, O’Reilly DS, Juhan-Vague I, Yudkin JS,
Tremoli E, Margaglione M, Di Minno G, Hamsten A, Kooistra T, Stephens JW, Hurel
SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N,
Humphries SE, Hingorani AD. Insight into the nature of the CRP-coronary event
association using Mendelian randomisation. Int J Epidemiol 2006,
35(4):922-931.
- Bautista LE.
Associations of microalbuminuria with inflammation markers in hypertensive men.
Am J Hypertens 2006, 19(5):467.
- Bautista LE.
Association of periodontitis with blood pressure. Blood Pressure 2006,
14: 383
- Hatzigeorgiou C, Taylor AJ,
Feuerstein IM, Bautista L, O’Malley PG. Antioxidant vitamin intake and
subclinical coronary atherosclerosis. Preventive Cardiology 2006,
9:75-81.
- Yusuf S, Hawken S, Ôunpuu S,
Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z,
Onen C, Lisheng L, Tanomsup S, Razak F, Sharma AM, Anand S, on behalf of the
INTERHEART Study Investigators. Obesity and the risk of myocardial infarction: a
case-control study in 27,000 subjects from 52 countries. Lancet 2005,
366: 1640-49.
- Bautista LE.
Association of C-Reactive
Protein With Blood Pressure. Arterioscler Thromb Vasc Bio, 2005, 25:
e137-e138.
- Herrán
OF, Bautista LE. Calidad de la dieta de la población adulta de Bucaramanga y su
patrón alimentario. Colomb Med 2005, 35:94-102.
- Casas JP,
Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and Stroke:
“Mendelian randomization”
provides further evidence for a causal link. Lancet 2005, 365:224-32.
- Bautista LE,
Herrán O.
Development and Validation of a Food
Frequency Questionnaire for the Colombian Population. Public Health Nutrition
2005, 8:181-188.
- Bautista LE,
Vera LM, Arenas IA, Gamarra G. Independent association between inflammatory
markers (C-reactive protein, interleukin-6, and TNF-α) and essential
hypertension. J Human Hypertens 2005, 19:149-154.
- Casas JP, Bautista LE,
Humphries SE, Smeeth L, Hingorani AD. Do Meta-analyses of Association studies of
Endothelial Nitric Oxide Synthase (eNOS) Variants and Ischaemic Heart Disease
Provide Conclusive Answers? Authors’ Reply. Circulation. 2004,
110:e305-e306.
- Casas JP, Hingorani AD, Bautista
LE, Sharma PJ. Meta-analysis of Genetic Studies in Ischaemic Stroke: 32
genes involving ~18,000 cases and ~58,000 controls. Arch Neurol 2004;
61:1652-1662.
- Bautista LE,
Atwood JE, O'Malley JP, Taylor AJ. Association Between C-reactive Protein and
Hypertension in Healthy Middle-Aged Men and Women. Coron Artery Dis.
2004; 15:331-336.
- Bautista LE,
Ardila ME, Gamarra G, Vargas CI, Arenas IA.
Angiotensin-Converting Enzyme Gene
Polymorphism and Risk of Acute Myocardial Infarction. Med Sci Monit
2004; 10:CR473-CR479.
- Casas JP, Bautista LE,
Humphries SE, Hingorani AD. Endothelial Nitric Oxide Synthase Genotype and
Ischaemic Heart Disease: Meta-Analysis of 26 Studies, Involving 23028 Subjects.
Circulation 2004; 109:1359-1365.
- Cubillos-Garzón
LA, Casas JP, Morillo CA, Bautista LE.
Congestive Heart Failure in
Developing Countries: The next epidemic. Am Heart J, 2004; 147(3):
412-417
- Bautista LE.
Inflammation, Endothelial Dysfunction, and the Risk of High Blood Pressure:
Epidemiologic and Biological Evidence. J Human Hypertens 2003:17(4):
223-230.
- Herrán
OF, Bautista L. Tabla de Composición de Preparaciones Consumidas en
Bucaramanga (Food Composition Table for Bucaramanga, Colombia).
CIE, Universidad
Industrial de Santander: Bucaramanga, Colombia. 2002.
- Bautista LE,
Vera LM, Villamil L, Silva SM, Peña IM, Luna L. Factores de riesgo asociados con
la prevalencia de hipertensión arterial en adultos de Bucaramanga, Colombia
(Risk factors associated to hypertension prevalence in adults from Bucaramanga,
Colombia). Salud Pública de México, 2002: 44(5):399-405
- Cubillos LA, Casas
JP, Silva F, Villamizar N, Lindarte M, Guzman JC, Bautista L, Duarte E,
López-Jaramillo P, and Morillo CA. Predicting Future Heart Failure Hospital
Admission in Myocardial Infarction Patients: Role of Risk Factor Assessment in a
Colombian Population. Journal of Cardiac Failure 2002; 8 (4): S65.
- Bautista LE,
Arenas IA, Peñuela A, Martínez LX. Total plasma homocysteine and risk of
cardiovascular disease: A meta-analysis of prospective cohort studies. J Clin
Epidemiol 2002; 55(9):882-887.
- Pradilla G,
Vesga Be, Leon Sarmiento Fe, Bautista Le, Nuñez Lc, Vesga E, Gamboa Nr.
Neuro-Epidemiology In The Eastern Region Of Colombia. Rev Neurol 2002;
34(11):1035-43.
- Mojica JL,
Meléndez HJ, Bautista LE. Timing of crystalloid administration and
incidence of cardiovascular side effects during spinal anesthesia: Results from
a randomized controlled trial. Anesthesia & Analgesia 2002;94:432-437.
- López-Jaramillo P, Casas JP,
Bautista LE, Serrano NC, Morillo CA. An integrated proposal to explain the
epidemic of cardiovascular disease in a developing country: From socio-economic
factors to free radicals. Cardiology 2001;96(1):1-6.
- Ounpuu S, Negassa A, Yusuf S, and
INTERHEART Investigators * (Colombia: Bautista L, Arenas IA, Casas JP). A
global study of risk factors for acute myocardial infarction. Am Heart J
2001;141:711-721.
-
Bautista LE, Herran OF,
Serrano C. Effects of palm oil and dietary cholesterol on plasma lipoproteins:
results from a dietary crossover trial in free-living subjects. Eur J Clin
Nutr 2001; 55(9): 748-754.
- Accini JL,
Sotomayor A, Trujillo F, Barera JG, Bautista L, Lopez-Jaramillo P.
Colombian study to assess the use of non-invasive determination of
endothelium-mediated vasodilation (CANDEV). Normal values and factors
associated. Endothelium 2001;8 (2):157-66.
-
Bautista LE, López-Jaramillo
P, Vera LM, Casas JP, Otero AP, Guaracao AI. Is C-reactive protein an
independent risk factor for essential hypertension? J Hypertens 2001;
19:857-861.
Courses Taught:
PHS 798: Epidemiologic Methodology
PHS 904: Special Topics in Epidemiology: Cardiovascular Diseases
Contact Information
Leonelo E. Bautista, M.D., M.P.H., Ph.D.
Department of Population Health Sciences
University of Wisconsin-Madison, Medical School
703 WARF
610 Walnut St.
Madison, WI 53726-2397
Phone: (608) 265-6176
Fax: (608) 263-2820
Email: lebautista@wisc.edu
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