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Karen J Cruickshanks, PhD

Research Area: Clinical research, Epidemiology
Keywords: Chronic Diseases, Aging

Professor of Ophthalmology and Visual Sciences, and of Population Health Sciences

Email: cruickshanks@episense.wisc.edu


Biography:

Dr. Cruickshanks completed her PhD in Epidemiology at the University of Pittsburgh Graduate School of Public Health in 1987 and has been a faculty member at UW-Madison since 1990. Her research program is studying the health problems of aging through epidemiological cohort studies. The Epidemiology of Hearing Loss Study (EHLS) is funded by the National Institute on Aging (AG11099) to study hearing, olfactory, and cognitive impairments in a population-based cohort of 3500 older residents of Beaver Dam, WI. The focus of this research is on the roles of inflammation and vascular factors on age-related disorders. In 2004, a new study of the adult offspring of the EHLS participants was funded by the National Institute of Aging, National Eye Institute and National Institute of Deafness and Other Communication Disorders (AG021917) to study the genetic and environmental factors which contribute to age-related sensory impairments. She is the Director of the EpiSense Audiometry Reading (EAR) Center for studying hearing in the Hispanic Community Health Study, a multi-center study of 16,000 Latinos, and the Epidemiology of Diabetes Interventions and Complications (EDIC) study . A major theme of her research is the link between subclinical atherosclerosis and the sensory and neurological disorders of aging.

Download Dr. Cruickshanks CV
 


Affiliations/Associations:

  • Institute on Aging, UW
  • Society for Epidemiologic Research
  • Association for Research in Vision and Ophthalmology
  • American Epidemiological Society
  • American Auditory Society
  • Association for Chemoreception Sciences
  • American Heart Association

Recent Honors/Awards:

  • 1983-1986 National Research Service Award, Pre-doctoral Fellowship, Diabetes Epidemiology
  • 1986 Student Leadership Service Certificate, Graduate School of Public Health, University of Pittsburgh
  • 1987 Outstanding Scholarship Award, Phi Delta Gamma, Kappa Chapter
  • 1987 Delta Omega Society, Omicron Chapter
  • 1998 Research to Prevent Blindness Lew R. Wasserman Merit Award
  • 1999 Elected to the American Epidemiological Society
  • 2002-2003 Alice R. McPherson, Retina Research Foundation Chair in Ophthalmology, University of Wisconsin Medical School
  • 2003-Date Data Monitoring and Oversight Committee, Multiethnic Pediatric Eye Survey and the Baltimore Pediatric Eye Survey, NEI
  • 2004-2005 Ad hoc Reviewer NAME (formerly ECDA) Study Section, NIH
  • 2004-2005 Institute of Medicine/National Research Council, Committee on Assessment of Noise-Induced Hearing Loss in the Military Service from WWII to the Present
  • 2006 Institute of Medicine/ National Research Council, Committee to Review the NIOSH Hearing Loss Research Program
  • 2007 National Deafness and Other Communication Disorders Advisory Council. NIH2007-Date Vision Committee, NIH Toolbox for Health Assessment
  • 2008-Date Epidemiology/Biostatistics Team NIH Toolbox meeting and workshop
  • 2008 Keynote Speaker. 20th Anniversary Symposium, National Institute on Deafness and Other Communication Disorders, National Institutes of Health: As Time Goes By: A Population Perspective on Hearing in Aging

Select Publications:

 
Nash SD, Cruickshanks KJ, Klein R, Klein BEK, Nieto JF, Huang GH, Pankow JS, Tweed TS.  The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study. Archives of Otolaryngology Head & Neck Surgery 2011;May;137(5):432-439. PMCID3096733.  www.ncbi.nlm.nih.gov/pubmed/21339392.
 
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, LettreG, Ongen H, Rajagopoaian R, Johnson T, Shen H, NelsonCP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, VanIperen EP, Gong Y, Price TS, Smith EN, Kim Ce, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Ghatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgoou C, Boer A, Drenos F, Eilbers CC, Fang JC, fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee De, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber Me, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmudaj JM,Clark R, Balmforth AJ, Danesh J, Day IN, Schork NJ, De Bakker PI, Delles C, Duggan D, Hingorani AD, JHirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M,. Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MOP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, Marz W, O’Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Guant TR, Anand SS, Van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ.  Meta-analysis of Dense Genecentric Association Studies reveals common and uncommon variants associated with height.  Am J Hum Genet 2011 Jan7;88(1):6-18. PMCID3014369.  www.ncbi.nlm.nih.gov/pubmed/21194676.
 
Nondahl DM, Cruickshanks KJ, Huang GH, Klein BEK, Klein R, Nieto JF, Tweed TS.  Tinnitus and its risk factors in the Beaver Dam Offspring Study.  Int J Audiology. 2011;May;50(5):313-320. PMCID3073029.  www.ncbi.nlm.nih.gov/pubmed/21309642.
 
Zhong W, Cruickshanks KJ, Huang GH, Klein BEK, Klein R, Nieto FJ, Pankow JS, Schubert CR.  Carotid atherosclerosis and cognitive function in midlife: the Beaver Dam Offspring Study.  Atherosclerosis 2011 Nov;219(1): 330-333. PMCID3206159.  www.ncbi.nlm.nih.gov/pubmed/21831374.
 
Zhan W, Cruickshanks KJ, Klein BEK, Klein R, Huang GH, Pankow JS, Gangnon RE, Tweed TS.  Modifiable determinants of hearing impairment in adults.  Preventive Medicine. 2011 Oct;53(4-5):338-342. PMCID3208793.  www.ncbi.nlm.nih.gov/pubmed/21871479.
 
Schubert CR, Cruickshanks KJ, Fischer ME, Huang GH, Klein BEK, Klein R, Pankow JS, Nondahl DM.  Olfactory impairment in an adult population: the Beaver Dam Offspring Study.  Chem Senses 2012 May;37(4):325-34. PMCIDPMC3325763.  www.ncbi.nlm.nih.gov/pubmed/22045704.
 
Fischer ME, Cruickshanks KJ, Pinto A, Schubert CR, Klein BE, Klein R, Nieto FJ, Pankow JS, Snyder DJ, Keating BJ.  Intensity of salt taste and prevalence of hypertension are not related in the Beaver Dam Offspring Study.  Chemosensory Perception 2012;5(2):139-145. PMCID3381604.  www.ncbi.nlm.nih.gov/pubmed/22745848.
 
Nondahl DM, Cruickshanks KJ, Huang GH, Klein BEK, Klein R, Tweed TW, Zhan W.  Generational differences in the reporting of tinnitus. Ear Hear 2012;33(5):640-644. PMCID3422442.  www.ncbi.nlm.nih.gov/pubmed/22588269.
 
Cruickshanks KJ, Wichmann MA.  Hearing impairment and other health conditions in older adults:  Chance associations or opportunities for prevention?  Semin Hear 2012;33:217-224.
 
Guo Y, Lanktree MB, Taylor KC, Fairfax BP, Elbers CC, Barnard J, Farrall M, Padmanabhan S, Baumert J, Almoguera Castillo B, Gaunt TR, Gong Y, Rajagopalan R, Romaine SPR, Kumari M, Rafelt S, Smith EN, Li YR, Sivapalaratnam S, van Iperen EPA, Speliotes EK, Toskala E, Zhang L, Ochs-Balcom HM, Bhangale TR, Chandrupatla HR, Drenos F, Gieger C, Gupta J, Johnson T, Kleber ME, Makino S, Mangino M, Meng Y, Nelson CP, Pankow JS, Pankratz N, Price TS, Shaffer J, Shen H, Tischfield S, Tomaszewski M, Atwood LD, Bailey KM, Balasubramanyam A, Baldwin CT, Basart H, Bauer F, Behr ER, Beitelshees AL, Berenson GS, Beresford SAA, Bezzina CR, Bhatt DL, Boer JMA, Braund PS, Burke GL, Burkley B, Carty C, Chen W, Clarke R, Cooper-DeHoff RM, Curtis SP, de Bakker PIW, de Jong JS, Delles C, Dominiczak AF, Duggan D, Feldman HI, Furlong CE, Gorski MM, Gums JG, Hardwick R, Hastie C, Held IM, Huang GH, Huggins GS, Humphries SE, Kirkland SA, Kivimaki M, Klein R, Klein BE, Knowler WC, Kottke-Marchant K, LaCroix AZ, Langaee TY, Li M, Lyon HN, Maiwald S, Marshall JK, Mehta A, Meijs MFL, Melander O, Meyer N, Mitra N, Molony CM, Morrow DA, Murugesan G, Newhouse SJ, Nieto JF, Onland-Moret NC, Ouwehand WH, Palmen J, Pepine CJ, Ranchalis J, Rosas SE, Rosenthal EA, Scharnagl H, Schork NJ, Schreiner PJ, Shah T, Shashaty M, Shimbo D, Srinivasan SR, Thomas F, Tobin MD, Tsai MY, Verschuren WMM, Wagenknecht LE, Winkelmann BR, Young T, Yusuf S, Zafarmand MH, Zmuda JM, Zwinderman AH, Anand SS, Balmforth AJ, Boehm BO, Boerwinkle E, Burton PR, Cappola TP, Casas JP, Caulfield MJ, Christiani DC, Christie J, Cruickshanks KJ, Davey-Smith G, Davidson KW, Day IN, Doevendans PA, Dorn II GW, FitzGerald GA, Hall AS, Hingorani AD, Hirschhorn JN, Hofker MH, Hovingh KG, Illig T, Jamshidi Y, Jarvik GP, Johnson JA, Kanetsky PA, Kastelein JJP, Koenig W, Lawlor DA, Marz W, McCaffery J, Mega JL, Mitchell BD, Murray SS, O’Connell JR, Patel SR, Peters A, Pettinger M, Rader DJ, Redline S, Reilly MP, Sabatine MS, Schadt EE, Shuldiner AR, Silverstein RL, Spector TD, Taylor HA, Thorand B, Trip MD, Watkins H, Wichmann HE, Fox CS, Grant SFA, Peter I, Talmud PJ, Munroe PB, Wilson JG, Knight JC, Samani NJ, Hegele RA, Asselbergs FW, Monda KL, van der Schouw YT, Demerath EW, Wijmenga C, Timpson NJ, Reiner AP, North KE, Papanicolaou GJ, Hakonarson H, Lange LA, Keating BJ.  Gene-centric meta-analyses of 108,912 individuals confirm known body mass index loci and reveal three novel signals.  Hum Mol Genet. 2013 Jan 1;22(1):184-201. PMCID3522401.  www.ncbi.nlm.nih.gov/pubmed/23001569.
 
Fischer ME, Schubert CR, Pinto A, Klein BEK, Klein R, Nieto JF, Pankow JS, Huang GH, Snyder DJ.  Taste intensity in the Beaver Dam Offspring Study.  Laryngoscope 2013 Jun;123(6):1399-1404. PMCID3664123.  www.ncbi.nlm.nih.gov/pubmed/23625687.
 
Asselbergs FW, Guo Y, Van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, Dejong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, Lacroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F.  Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.  Am J Hum Genet 2012 Nov 2;91:(5):823-838. PMCID3487124.  www.ncbi.nlm.nih.gov/pubmed/23063622.
 
Nash SD, Cruickshanks KJ, Huang GH, Klein BEK, Klein R, Nieto J, Tweed TS.  Unmet hearing health care needs: The Beaver Dam Offspring Study.  Am J Public Health 2013 Jun;103(6):1134-1139. PMCID3670658  www.ncbi.nlm.nih.gov/pubmed/23597370.
 
Schubert CR, Cruickshanks KJ, Fischer ME, Huang GH, Klein R, Pankratz N, Zhong W, Nondahl DM.  Odor identification and cognitive function in the Beaver Dam Offspring Study.  J Clin Exp Neuropsychol 2013;35(7):669-76. PMCID3778079.  http://dx.doi.org/10.1080/13803395.2013.809701.
 
Fischer ME, Cruickshanks KJ, Schubert CR, Pinto A, Klein R, Pankratz N, Pankow J, Huang GH.  Factors related to fungiform papillae density: the Beaver Dam Offspring Study.  Chem Senses 2013 Oct;38(8):669-677. PMCID3777560.  www.ncbi.nlm.nih.gov/pubmed/23821729.

Zhan W, Cruickshanks KJ, Klein BEK, Klein R, Huang GH, Pankow JS, Gangnon RE, Tweed TS. Modifiable determinants of hearing impairment in adults. Prev Med 2011;53(4-5):338-342. PMCID3208793.

Shankar A, Sun L, Klein BEK, Lee KE, Munter P, Nieto FJ, Tsai MY, Cruickshanks KJ, Schubert CR, Brazy PC, Coresh J, Klein R. Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population based cohort study. Kidney Int 2011;80(11):1231-1238. PMCID3260339.

Sabanayagam C, Shankar A, Klein BEK, Lee KE, Muntner P, Nieto J, Tsai MY, Cruickshanks KJ, Schubert CR, Brazy PC, Coresh J, Klein R. Bidirectional association of retinal vessel diameters and estimated glomerular filtration rate decline: The Beaver Dam CKD Study. Am J Kidney Dis 2011;57(5):682-691. PMCID3080044.

Nondahl DM, Tweed TS, Cruickshanks KJ, Wiley TL, Dalton DS. Aging and the 4 kHz air-bone gap. J Speech Lang Hear Res 2012;55(4):1128-1134. PMCID3326193.

Nondahl DM, Cruickshanks KJ, Huang GH, Klein BEK, Klein R, Tweed TW, Zhan W. Generational differences in the reporting of tinnitus. Ear Hear 2012;33(5):640-644. PMCID3422442.

Zhong W, Cruickshanks KJ, Schubert CR, Acher CW, Carlsson CM, Klein BEK, Klein R, Chappell. Carotid atherosclerosis and 10-year changes in cognitive function. Atherosclerosis. 2012 Oct;224(2):506-510. PMCID3459157.

Klein R, Cruickshanks KJ, Myers CE, Sivakumaran TA, Iyengar SK, Meuer SM, Schubert CR, Gangnon R, Klein BEK. The relationship of atherosclerosis to the 10-year cumulative incidence of age-related macular degeneration: the Beaver Dam Studies. Ophthalmology 2013 May;120(5):1012-1019. PMCID3646961.

Wichman MA, Cruickshanks KJ, Nondahl DM, Chappell R, Klein BE, Klein R, Fischer M. Changes in environmental tobacco smoke exposure: The Beaver Dam Experience. Wisconsin Medical Journal. 2013 April;112(2):53-57. PMCID3682678.

Obasi CN, Cruickshanks KJ, Nondahl DM, Klein BE, Klein R, Nieto J, Shankar A, Fischer ME, Tsai MY, Chappell R. Association of biomarkers for inflammation, endothelial dysfunction and oxidative stress with cognitive impairment. The Epidemiology of Hearing Loss Study. Oxid Antioxid Med Sci. 2012 June 26;1(3): 169-173. PMCID3693393.

Zhong W, Cruickshanks KJ, Schubert CR, Carlsson CM, Chappell RJ, Klein BEK, Klein R, Acher CW. Pulse wave velocity and cognitive function in older adults. Alzheimer Disease & Associated Disorders. 2013 Apr 28 (Epub ahead of print) In Press. PMCID3778043.

Nondahl DM, Cruickshanks KJ, wiley TL, Tweed TS, Dalton DS. 16-year change in acoustic admittance measures among older adults: data from a population-based study. J Speech Lang Hear Res. 2013 Sep 10; (Epub ahead of print) NIHMSID# 477448. PMCID PMC – Journal in Process.

Nash SD, Cruickshanks KJ, Schubert CR, Klein R, Klein BEK, Nieto JF, Chappell R, Tsai M. Long-term variability of inflammatory markers in a population-based cohort. J Am Geriatr Soc 2013 Aug;61(8):1269-76. PMCID3743937.
 

 

Research Weblinks:

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Contact Information:

Address:
1038 WARF Building
610 Walnut Street
Madison, WI 53726

Phone: 608-262-4032
Fax: 608-256-9665
Email: cruickshanks@episense.wisc.edu

 

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