Karen J Cruickshanks, PhD

Professor of Ophthalmology and Visual Sciences, and of Population Health Sciences

Email: cruickshanks@episense.wisc.edu

Biography:

Dr. Cruickshanks completed her PhD in Epidemiology at the University of Pittsburgh Graduate School of Public Health in 1986 and has been a faculty member at UW-Madison since 1990. Her research program is studying the health problems of aging through epidemiological cohort studies. The Epidemiology of Hearing Loss Study (EHLS), now in its 16th year, is funded by the National Institute on Aging (AG11099) to study hearing, olfactory, and cognitive impairments in a population-based cohort of 3500 older residents of Beaver Dam, WI. The focus of this research is on the roles of inflammation and vascular factors on age-related disorders. In 2004, a new study of the adult offspring of the EHLS participants was funded by the National Institute of Aging, National Eye Institute and National Institute of Deafness and Other Communication Disorders (AG021917) to study the genetic and environmental factors which contribute to age-related sensory impairments. She is the PI of the EpiSense Audiometry Reading (EAR) Center for the Hispanic Community Health Study, a multi-center study including hearing testing for 16,000 Latinos. A major theme of her research is the link between subclinical atherosclerosis and the sensory and neurological disorders of aging.

Affiliations/Associations:

• Institute on Aging, UW
• Society for Epidemiologic Research
• Association for Research in Vision and Ophthalmology
• American Epidemiological Society
• American Auditory Society
• Association for Chemoreception Sciences
• American Heart Association

Recent Honors/Awards:

• 1983-1986 National Research Service Award, Pre-doctoral Fellowship, Diabetes Epidemiology
• 1986 Student Leadership Service Certificate, Graduate School of Public Health, University of Pittsburgh
• 1987 Outstanding Scholarship Award, Phi Delta Gamma, Kappa Chapter
• 1987 Delta Omega Society, Omicron Chapter
• 1998 Research to Prevent Blindness Lew R. Wasserman Merit Award
• 1999 Elected to the American Epidemiological Society
• 2002-2003 Alice R. McPherson, Retina Research Foundation Chair in Ophthalmology, University of Wisconsin Medical School
• 2003-Date Data Monitoring and Oversight Committee, Multiethnic Pediatric Eye Survey and the Baltimore Pediatric Eye Survey, NEI
• 2004-2005 Ad hoc Reviewer NAME (formerly ECDA) Study Section, NIH
• 2004-2005 Institute of Medicine/National Research Council, Committee on Assessment of Noise-Induced Hearing Loss in the Military Service from WWII to the Present
• 2006 Institute of Medicine/ National Research Council, Committee to Review the NIOSH Hearing Loss Research Program
• 2007 National Deafness and Other Communication Disorders Advisory Council. NIH2007-Date Vision Committee, NIH Toolbox for Health Assessment
• 2008-Date Epidemiology/Biostatistics Team NIH Toolbox meeting and workshop
• 2008 Keynote Speaker. 20th Anniversary Symposium, National Institute on Deafness and Other Communication Disorders, National Institutes of Health: As Time Goes By: A Population Perspective on Hearing in Aging.

Select Publications:

Dalton DS, Cruickshanks KJ, Wiley TL, Klein BEK, Klein R, Tweed TS: Association of leisure time noise exposure and hearing loss. Audiology 40:1-9, 2001.

Klein BEK, Cruickshanks KJ, Nondahl DM, Klein R, Dalton DS: Cataracts and hearing loss in a population-based study: The Beaver Dam Studies. Am J Ophthalmol 132:537-543, 2001.

Wong TY, Cruickshanks KJ, Klein R, Klein BEK, Moss SE, Palta M, Riley WJ, Maclaren NK, Vadheim CM, Rotter JI: HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy. Ophthalmology 109(2):275-281, 2002.

Nondahl DM, Cruickshanks KJ, Klein R, Klein BEK, Wiley TL, Tweed TS, Pasic TR: Prevalence and 5- year incidence of tinnitus among older adults: The Epidemiology of Hearing Loss Study. J Am Acad Audiol 13:323-331; 2002.

Murphy C, Schubert CR, Cruickshanks KJ, Klein BEK, Klein R, Nondahl DM,: Prevalence of olfactory impairment in older adults: Results of an epidemiological study. JAMA 288(18):2307-2312; 2002.

Schubert CR, Cruickshanks KJ, Dalton DS, Klein BEK, Klein R, Nondahl DM: Prevalence of sleep problems and quality of life in an older population. Sleep 25(8):889-93; 2002.

Klein R, Klein BEK, Wong TY, Tomany SC, Cruickshanks KJ. The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy. The Beaver Dam Eye Study. Arch Ophthalmol 120:1551-1558; 2002.

Klein BEK, Moss SE, Klein R, Lee KE, LG, Cruickshanks KJ: Associations of visual function with physical outcomes and limitations 5 years later in an older population: the Beaver Dam eye study. Ophthalmology. 110(4):644-50,2003.

Klein R, Klein BEK, Tomany SC, Danforth LG, Cruickshanks KJ: Relation of statin use to the 5-year incidence and progression of age-related maculopathy. Archives of Ophthalmology. 121(8):1151-5,2003.

Torre P, Cruickshanks KJ, Nondahl DM, Wiley TL: Distortion product otoacoustic emission (DPOAE) response characteristics in older adults. Ear and Hearing; 24:20-29; 2003.

Klein R, Klein BEK, Tomany SC, Cruickshanks KJ: Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy. Archives of Ophthalmology, 121 (5):674-8; 2003.

Klein R, Klein BEK, Tomany SC, Cruickshanks KJ: The association of cardiovascular disease with the long-term incidence of age-related maculopathy, The Beaver Dam Eye Study. Reprinted in Ophthalmology; 110: 636-643, 2003.

Klein BEK, Moss SE, Klein R, Lee KE, Cruickshanks KJ: Associations of visual function with physical outcomes and limitations five years later in an older population, The Beaver Dam Eye Study. Ophthalmology; 110:644-650; 2003.

Dalton DS, Cruickshanks KJ, Klein BEK, Klein R, Wiley TL, Nondahl DM: The impact of hearing loss on quality of life in older adults. The Gerontologist, 45(5): 661-668, 2003.

Mitchell J, Cruickshanks KJ, Klein BEK, Palta M, Nondahl DM: Is postmenopausal hormone replacement therapy use associated with cognitive impairment? Arch Intern Med, 163: 2485-2490, 2003.

Cruickshanks KJ, Tweed TS, Wiley, TL, Klein BEK, Klein R, Chappell RJ, Nondahl DM, Dalton DS: The five-year incidence and progression of hearing loss: The Epidemiology of Hearing Loss Study. Arch Otolaryngol Head Neck Surg, 129: 1041-1046, 2003.

Klein R, Klein BEK, Moss S, Wong T, Hubbard L, Cruickshanks KJ, Palta M: The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: The Wisconsin Epidemiological Study of Diabetic Retinopathy. Arch Ophthalmol, 122 (1):76-83; 2004.

Tomany SC, Cruickshanks KJ, Klein R, Klein BEK, Knudtson MD: Sunlight and the 10-Year Incidence of Age-related Maculopathy: The Beaver Dam Eye Study. Arch Ophthalmol, 122(5):750-7, 2004.

Nondahl DM, Cruickshanks KJ, Dalton DS, Schubert CR, Klein BEK, Klein R, Tweed TS. Serum cotinine and incident hearing loss: a case/control study. Arch Otolaryngol–Head & Neck Surgery. 130:1260-1264, 2004.

Nondahl DM, Schubert CR, Cruickshanks KJ. A questionnaire for assessing environmental tobacco smoke exposure. Environmental Research. 2005(97):76-82.

Klein BEK, Klein R, McBride PE, Cruickshanks KJ, Palta M, Knudtson MD, Moss SE, Reineke JO: Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Intern Med 2004;164:1917-1924.

Puent B, Klein BEK, Klein R, Cruickshanks KJ, Nondahl DM: Factors Related to Vision Care in an Older Adult Cohort. Optom Vis Sci. 82 (7): 612-616, 2005.

Wiley TL, Nondahl DM, Cruickshanks KJ, Tweed TS: Five-year changes in middle ear function for older adults. J Am Acad Audiol. Mar;16(3):129-39, 2005.

Torre P, Cruickshanks KJ, Klein BEK, Klein R, Nondahl DM: The association between cardiovascular disease and cochlear function in older adults. J Speech Lang Hear Res. Apr;48(2): 473-81, 2005.

Knudtson MD, Klein BEK, Klein R, Cruickshanks KJ, Lee KE: Age-Related Eye Disease, Quality of Life, and Functional Activity. Arch Ophthalmol. 123:807-814, 2005.

Committee on Noise-Induced Hearing Loss and Tinnitus Associated with Military Service from World War II to the Present: Noise and Military Service: Implications for Hearing Loss and Tinnitus LE Humes, LM Joellenbeck, and JS Durch (Editors), National Academies Press, Washington, DC, 2005.

Klein R, Klein BE, Lee KE, Cruickshanks KJ, Gangnon RE. Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study. Am J Ophthalmol 142:539-49, 2006.

Nondahl DM, Cruickshanks KJ, Dalton DS, Klein BEK, Klein R, Schubert CR, Tweed TS, Wiley TL. The impact of tinnitus on quality of life in older adults. J Am Acad Audiol 18(3):259-268, 2007.

Nondahl DM, Cruickshanks KJ, Dalton DS, Klein BEK, Klein R, Tweed TS, Wiley TL. The use of hearing protection by older adults during recreational noise exposure. Noise and Health 8:147-153, 2006.

Trentham-Dietz A, Sprague BL, Klein R, Klein B, Cruickshanks KJ, Fryback DG, Hampton JM. Health–Related Quality of Life Before and After a Breast Cancer Diagnosis. Breast Cancer Res Treat. 109(2): 379-87, 2008. Epub 2007, Aug 3. PMID: 17674200.

Klein R, Knudtson MD, Cruickshanks KJ, Klein BEK. Further observations on the association between smoking and the long-term incidence and progression of age related macular degeneration: the Beaver Dam Eye Study. Arch Ophthalmol. Jan;126(1)115-21, 2008.

Wiley TL, Chappell R, Carmichael L, Nondahl DM, Cruickshanks KJ. Changes in hearing thresholds over 10 years in older adults. J Am Acad Audiol. April; 19(4) 281-292, 2008.

Schubert CR, Carmichael LL, Murphy C, Klein BEK, Klein R, Cruickshanks KJ. Olfaction and the 5-year incidence of cognitive impairment in an epidemiologic study of older adults. JAGS. In Press.

Sprague BL, Trentham-Dietz A, Klein BEK, Klein R, Cruickshanks KJ, Lee KE, Hampton JM. Physical Activity, White Blood Cell Count, and Lung Cancer Risk in a Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev. Oct;17(10), 2008.

Carlsson CM, Nondahl DM, Klein BEK, McBride PE, Sager MA, Schubert CR, Klein R, Cruickshanks KJ. Increased Atherogenic Lipoproteins are associated with cognitive impairment: Effects of statins and subclinical atherosclerosis. Alz Dis Assoc Disord 2009;23;11-17.

Schubert CR, Cruickshanks KJ, Murphy C, Huang GH, Klein BEK, Klein R, Nieto FJ, Pankow JS, Tweed TS. Olfactory Impairment in Adults: The Epidemiology of Hearing Loss Study and the Beaver Dam Offspring Study. Annuals of the New York Academy of Sciences. In press.

Cruickshanks KJ, Schubert CR, Snyder DJ, Bartoshuk LM, Huang GH, Klein BEK, Klein R, Nieto FJ, Pankow JS, Tweed TS, Krantz EM. Measuring Taste Impairment in Epidemiologic Studies – The Beaver Dam Offspring Study. Annals of the New York Academy of Sciences. In press.

Hoffman H, Cruickshanks KJ, Davis B. Perspectives on population-based epidemiological studies of olfactory and taste impairment. Annals of the New York Academy of Sciences. In press.

Research Weblinks:

BOSS

Contact Information:

Address:
610 Walnut Street
Room 1038, WARF Building
Madison, WI 53726

Phone: 608-262-4032
Fax: 608-256-9665
Email: cruickshanks@episense.wisc.edu