Jerome A. Dempsey, Ph.D

 

Jerry is the director of the John Rankin Laboratory of Pulmonary Medicine located on the West side of the campus at 504 N. Walnut Street. He has his primary appointment in the Department of Population Health Sciences and affiliate appointments in Physiology and Kinesiology. His research interests are concerned with the regulation of breathing in various physiologic states in unanesthetized humans and animals. One group of projects seeks to determine the limits of the healthy human pulmonary system for gas transport, respiratory muscle function and ventilatory output during exercise. The effects of aging, gender, fitness and airway reactivity on these processes are emphasized. A second major aim is the influence of respiration on autonomic control of cardiovascular function. A third series of studies is concerned with regulation of breathing in waking and sleeping humans and animals, with specific emphasis on sleep apnea and the effects of states. Jerry teaches in the undergraduate Biocore program, the graduate Kinesiology program and in the Medical School physiology course. He also supervises the research of undergraduate and graduate students and post-doctorate fellows. He collaborates closely with several other faculty, including Curtis Smith, Barbara Morgan and James Skatrud. Jerry is an associate editor of the Journal of Applied Physiology. Affiliations/Associations: Associate Editor: Journal of Physiology and Journal of Applied Physiology NHLBI Parent Review Committee for Program Project Grants. Recent Honors/Awards: Gollnick Memorial Lecturer, American College of Sports Medicine, June, 2001 Representative Publications: Wetter, T.J., Z. Xiang, D.A. Sonetti, H.C. Haverkamp, A.J. Rice, A.A. Abbasi, K.C. Meyer, and J.A. Dempsey. Role of lung inflammatory mediators as a cause od exercise-induced arterial hypoemia in young athletes. J Appl Physiol 93: 116-126, 2002. Sheel, A.W., P.A. Derchak, D.F. Pegelow, and J.A. Dempsey. Threshold effects of respiratory muscle work on limb vascular resistance. Am J Physiol Heart Circ Physiol 282: H1732-H1738, 2002. Dempsey, J.A., A.W. Sheel, C.M. St. Croix, and B.J. Morgan. Respiratory influences on sympathetic vasomotor outflow in humans. Frontier's in Science Invited Review, Respiratory Physiol & Neurobiology 130: 3-20, 2002. Nakayama, H., C.A.Smith, J.R. Rodman, J.B. Skatrud, and J.A. Dempsey. Effect of ventilatory drive on CO2 sensitivity below eupnea during sleep. Am J Respir Crit Care Med 165: 1251-1259, 2002. Dempsey, J. A. and J. B. Skatrud (2001). "Apnea following mechanical ventilation may be caused by nonchemical neuromechanical influences." American Journal of Respiratory & Critical Care Medicine 163(6): 1297-8. Dempsey, J.A., and P.D. Wagner. Exercise-induced arterial hypoxemia (Invited Brief Review) J. Appl. Physiol. 87: 1997-2006, 1999. Eastwood**, P.R., M. Satoh**, A.K. Curran, M.T. Zayas, C.A. Smith, and J.A. Dempsey. Inhibition of inspiratory motor output by high-frequency low-pressure oscillations in the upper airway of sleeping dogs. J. Physiol. 517.1:259-271, 1999. Harms, C.A., and J.A. Dempsey. Cardiovascular consequences of exercise hyperpnea. In: Exercise and Sport Sciences Reviews, edited by J.O. Holloszy, Lippincott, Williams & Williams, Philadelphia, 1999, pp. 37-62. St. Croix**, C.M., T.J. Wetter*, D.F. Pegelow, K.C. Meyer, and J.A. Dempsey. Assessment of nitric oxide formation during exercise. Am J. Respir Crit Care Med, 159:1125-1133, 1999. Wilson**, CR., M. Satoh**, J.B. Skatrud, and J.A. Dempsey. Non-chemical inhibition of respiratory motor output during mechanical ventilation in sleeping humans. J. Physiol. 518.2: 605-618, 1999. Harms**, C.A.**, T. Wetter*, J.A. Dempsey. Breathing in Exercise, In: Rehabilitation of the Patient with Respiratory Disease. NS Cherniak, MD Altose, and I Homma (eds.), Mc-Graw-Hill, New York, 1999, pp. 87-96. Wetter*, T.J., C.A. Harms**, W.B. Nelson, D.F. Pegelow, and J.A. Dempsey. Influence of respiratory muscle work on VO2 and leg blood flow during submaximal exercise. J. Appl. Physiol. 87(2): 643-651, 1999. McClaran*, S.R., T.J. Wetter*, D.F. Pegelow, and J.A. Dempsey. Role of expiratory flow limitation in detrmining lung volumes and ventilation during exercise. J. Appl. Physiol. 86(4):1357-1366, 1999. St. Croix**, C.M., M. Satoh**, B.J. Morgan, J.B. Skatrud, and J.A. Dempsey. Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity. Circ. Research, 85: 457-469, 1999. * pre-doctoral   ** post-doctoral Contact Information Jerome A. Dempsey, Ph.D. Department of Population Health Sciences 4245 Medical Sciences Center 1300 University Ave Madison, WI 53706 Phone: (608) 263-1732 Fax: (608) 262-8235 Email: jdempsey@facstaff.wisc.edu Web site: http://www.vetmed.wisc.edu/cbs/mitchell/rntp/index.htm