|
Dr. Smith is the Director of the Biogerontology Laboratory in the Department of
Population Health Sciences at the University of Wisconsin-Madison. A specialist in the science of exercise physiology and bone metabolism, he has conducted extensive research on the benefits of exercise and diet in the prevention of osteoporosis. He travels and lectures extensively and is widely published in the areas of exercise and aging, and osteoporosis. He has also conducted research in the biology of aging and has developed tools to evaluate the fitness of older adults such as a chair-step test and modified bike and treadmill tests. During the last three years he has expanded his research interest to in include bone organ culture. Small segments of trabecular from either a pig or a cow have been maintained in culture medium for 30 to 60 days. This expanded research interest, will provide insights into the control mechanism of bone modeling and remodeling in response to mechanical load, aging, drug therapy and disease. The new research will open new avenues for the diagnosis and treatment of osteoporosis. Understanding the control mechanism of bone metabolism are key to the prevention of many of the chronic bone diseases that are classified as major population health problems now and for the future.
Dr. Smith is on three editorial boards and is guest editor for numerous journals. He is a fellow of the American College of Sports Medicine and a member of the University of Wisconsin Institute on Aging. In 1984, he founded the National Institute of Biogerontology, an organization designed to provide research and education on the prevention of osteoporosis and physiological changes with age.
Dr. Smith's laboratory, in conjunction with the laboratory of Dr. David Jones, Marburg Germany, have developed a new Perfusion-Loading System (PLS) which provides the ability to study bone cores (containing 2 million cells) and cartilage under controlled environmental conditions. The computer controlled piezoelectric actuator permits either bone or cartilage specimens to be, precisely loaded. Research using the perfusion system has shown it can maintain viable bone cells for over 30 days in their natural matrix. The PLS not only permits long term maintenance but also permits real time measurements of both compression and loading of these viable cells.
Worldwide patent applications have been filed covering the major innovations in both the equipment and sample preparation.
The immediate objectives are to study the changes in bone and cartilage under controlled loads and a variety of biochemical stimuli. The research outcomes will also accelerate our understanding of, and hasten drug development and treatment for, both osteoarthritis and osteoporosis.
Affiliations/Associations:
Topics in Geriatric Rehabilitation, 1985-present
Calcified Tissue International, 1991-present
Journal of Aging and Physical Activity, 1993-1998
Issue Editor, Exercise and Aging, Topics in Geriatric Rehabilitation, Volume I Number 1, October 1985.
Issue Editor, Bone Changes with Age, Topics in Geriatric Rehabilitation, Volume 4 Number 2, January 1989.
Issue Editor, Joint Changes with Age, Topics in Geriatric Rehabilitation, Volume 4 Number 3, April 1989.
Issue Editor, Osteoporosis Revisited, Topics in Geriatric Rehabilitation, Volume 10 Number 4, June 95.
Guest Referee, Medicine and Science in Sports and Exercise, 1980-present
Guest Referee, Journal of Gerontology, 1985-present
Guest Referee, Physician and Sportsmedicine, 1985-present
Guest Editor, Physician and Sports Medicine, Symposium on Osteoporosis, November 1987 issue
Guest Editor, Journal of Bone and Mineral Research, 1987-present
Guest Editor, The American Physiological Society, 1992-present
Guest Editor, Osteoporosis International, 1993-present
President, National Institute of Biogerontology, 1984-present
Institute on Aging Education Committee, 1992-present
National Institute of Aging Monitoring Board for FICSIT, 1990-1994
Recent Honors/Awards:
Teaching Award 1999 from the Institute On Aging, University of Wisconsin
Representative Publications:
Smith E.L., M.M. Checovich, C. Rosen. Effect of Physical Training on Bone Mineral Density in Septuagenarian Women. Calcified Tissue International,
1999.
Checovich, M.M., and E.L. Smith, Bone. In Manual of Geriatric Rehabilitation (ed. Timothy L. Kauffman), in press 1998
Smith E.L., M. Kratz, P. Zigrino, V. Pavone, D.B. Jones. An Explant Model For Bone Regulatory Mechanisms of Mechanical Loading Presented at Sun Valley Hard Tissue Research Conference 1998.
Smith, E.L. Dose response relationship between physical loading and mechanical competence of bone. Bone, 10(1 S):45S-50S, 1996.
Smith, E.L., L. Tommerup. Exercise: A prevention and treatment for osteoporosis and injurious falls in the older adult. J Aging and Physical Activity. 3(2):178-192, 1995.
Smith, E.L. The role of exercise in the prevention and treatment of of osteoporosis. Topics in Geriatric Rehabilitation 10(4):55-63, 1995.
Tommerup, L.J., D.M. Raab, T.D. Crenshaw and E.L. Smith. Does weightbearing exercise affect non-weightbearing bone? ASBMR, August 1993.
Courses Taught:
PHS 155: Introduction to the Biology of Aging
PHS 575: The Biological Process of Aging
PHS 576: Biogerontology Seminar
Contact Information
Everett L. Smith, Ph.D.
Department of Population Health Sciences
University of Wisconsin Medical School
504 North Walnut Street, Room 1
Madison, Wisconsin 53705-2368 USA
Phone: (608) 263-2878
Fax: (608) 262-8235
Email: elsmith1@facstaff.wisc.edu
|
