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Corinne D Engelman, MSPH, PhD

Research Area: Epidemiology
Keywords: Vitamin D, Genetic Epidemiology, Cognitive Function, Alzheimer’s, Aging


Assistant Professor of Population Health Sciences

Email: cengelman@wisc.edu


Biography:

Dr. Engelman is a genetic epidemiologist interested in complex diseases and quantitative traits of aging such as type 2 diabetes, insulin resistance, Alzheimer's disease, cognitive function, and vitamin D deficiency. She is particularly interested in gene-gene and gene-environment interactions and methodologic approaches to studying the genetic contribution to complex phenotypes.

One major area of research is the genetic and non-genetic factors associated with vitamin D. Vitamin D deficiency is associated with many adverse health outcomes, including bone diseases, cancer, autoimmune diseases, infections, diabetes and the metabolic syndrome, hypertension, cardiovascular disease, and cognitive decline, making vitamin D an important health outcome of interest. Dr. Engelman is currently studying the genetic, demographic, behavioral, physiological, and environmental correlates of vitamin D levels in the blood and of the association between vitamin D and other health outcomes, such as blood pressure and lipid concentrations, in Caucasians from the Survey of the Health of Wisconsin (SHOW).

Dr. Engelman is also studying the genetic and non-genetic determinants of cognitive decline in the Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort study of asymptomatic middle-aged adults enriched for a parental history of Alzheimer's disease. She is particularly interested in genes recently reported by genome-wide association studies of Alzheimer's, genes that may be in the physiologic pathway of both Alzheimer's and type 2 diabetes, and vitamin D-related genes. Dr. Engelman is also examining the role of interactions between genes and with non-genetic factors in determining cognitive function and decline.

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Affiliations/Associations:

  • Alzheimer's Disease Research Center, University of Wisconsin
  • American Society of Human Genetics
  • Genome Center of Wisconsin, University of Wisconsin
  • Institute on Aging, University of Wisconsin
  • International Genetic Epidemiology Society
  • International Society to Advance Alzheimer Research and Treatment

Recent Honors/Awards:

  • Public Health/Epidemiology Traineeship, 2001
  • University of Alabama at Birmingham Short Course in Statistical Genetics Scholarship, 2003
  • Society of Epidemiologic Research Student Workshop Scholarship, 2005
  • Teaching Academy Summer Institute Award, 2007
  • Selected for the AAMC Early Career Women Faculty Professional Development Seminar 2010
  • Outstanding Young Investigator in Alzheimer's disease, 2012

Select Publications:

Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA.  Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer’s Prevention.  J Alzheimers Dis 2013 (in press).

Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, La Rue A, Sager MA.  Stressful Events, Social Support, and Cognitive Function in Middle-aged Adults with a Family History of Alzheimer’s Disease.  J Aging Health 2013 (in press).

Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ.  Prediction of Genetic Contributions to Complex Traits using Whole Genome Sequencing Data.  BMC Proceedings 2013 (in press).

Meyers KJ, Johnson EJ, Bernstein PS, Iyengar SK, Engelman CD, Karki CK, Liu Z, Igo Jr. RP, Truitt B, Klein M, Snodderly DM, Blodi B, Gehrs K, Sarto G, Wallace R, Robinson J, LeBlanc E, Hageman G, Tinker L, Mares JA.  Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study.  Invest Ophthalmol Vis Sci 2013 Mar 28;54(3):2333-2345.

Hale L, Hill TD, Friedman E, Nieto FJ, Galvao LW, Engelman CD, Malecki KM, Peppard PE.  Perceived neighborhood quality, sleep quality, and health status: Evidence from the Survey of the Health of Wisconsin.  Soc Sci Med 2013 Feb;79:16-22.

Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo, Jr RP, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE.  External Sources of Vitamin D Modify the Effects of the GC and CYP2R1 Genes on 25-Hydroxyvitamin D Concentrations. J Nutr 2013 Jan;143:1-10.

Ghosh S, Bickeböller H, Bailey J, Bailey-Wilson JE, Cantor R, Culverhouse R, Daw W, Destefano AL, Engelman CD, Hinrichs A, Houwing-Duistermaat J, König IR, Kent J Jr, Laird N, Pankratz N, Paterson A, Pugh E, Suarez B, Sun Y, Thomas A, Tintle N, Zhu X, Ziegler A, Maccluer JW, Almasy L.  Identifying rare variants from exome scans: the GAW17 experience.  BMC Proceedings 2011 Nov; 5(S9):S1:1-4.

Ye KQ and Engelman CD.  Detecting Multiple Causal Rare Variants in Exome Sequence Data. Genet Epidemiol 2011;35(S1):S18-21.

Bueno Filho JS, Morota G, Tran QT, Maenner MJ, Vera-Cala LM, Engelman CD, Meyers KJ.  Analysis of human mini-exome sequencing data using a Bayesian hierarchical mixture model: Genetic Analysis Workshop 17. BMC Proceedings 2011 Nov;5(S9):S93:1-8.

Engelman CD.  Editorial: Vitamin D recommendations: the saga continues.  J Clin Endocrinol Metab 2011 Oct;96(10):3065-6.

Kluczynski MA, LaMonte MJ, Mares JA, Wactawski-Wende J, Smith AW, Engelman CD, Andrews CA, Snetselaar LG, Sarto GE, Millen AE.  Duration of Physical Activity and Serum 25-hydroxyvitamin D Status of Postmenopausal Women.  Ann Epidemiol 2011 Jun;21(6):440-449.

Nieto FJ, Peppard PE, Engelman CD, McElroy JA, Galvao LW, Friedman EM, Bersch AJ, Malecki KC.  The Survey of the Health of Wisconsin (SHOW), a novel infrastructure for population health research: rationale and methods.  BMC Public Health 2010 10:785.

Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Rotter JI, Bowden DW, Langefeld CD, Norris JM.  Genome-wide association study of vitamin D concentrations in Hispanic Americans: The IRAS Family Study.  J Steroid Biochem Mol Biol 2010 Oct;122(4):186-92.

Young K, Engelman CD, Fingerlin TE, Langefeld CD, Haffner SM, Bryer-Ash M, Hanley AJG, Bergman R, Norris JM.  Association of 25-hydroxyvitamin D with Baseline and Follow-up Measures of Glucose Homeostasis and Incident Diabetes in Hispanic and African Americans: the IRAS Family Study. In press J Clin Endocrinol Metab 2010.

Bendlin BB, Carlsson CM, Gleason CE, Johnson SC, Sodhi A, Gallagher CL, Puglielli L, Engelman CD, Ries ML, Xu G, Wharton W, Asthana S. Midlife predictors of Alzheimer’s disease. Maturitas 2010 Feb;65(2):131-7.

Maenner MJ, Denlinger LC, Langton A, Meyers KJ, Engelman CD, Skinner HG. Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests. BMC Proceedings 2009 Dec;3(S7):S88.

Yao L, Zhong W, Zhang Z, Maenner MJ, Engelman CD. Classification tree for selection of single-nucleotide polymorphism (SNP)-by-SNP interactions related to heart disease: Framingham Heart Study. BMC Proceedings 2009 Dec;3(S7):S83.

González-Recio O, López de Maturana E, Vega AT, Engelman CD, Broman KW.  Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model. BMC Proceedings 2009 Dec;3(S7):S63.

Shim H, Chun H, Engelman CD, Payseur BA. Genome-wide association studies using single-nucleotide polymorphisms versus haplotypes: an empirical comparison with data from the North American Rheumatoid Arthritis Consortium. BMC Proceedings 2009 Dec;3(S7):S35.

Engelman CD, Baurley JW, Chiu YF, Joubert BR, Maenner MJ, Murcray CE, Shi G, Gauderman, WJ. Detecting Gene-Environment Interactions in Genome-Wide Association Data. Genet Epidemiol 2009 Nov;33(S1):S68-S73.

An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang C, Zheng T, Kovac IP, Dubé M, Liang X, Li J, Andrade M, Culverhouse R, Malzahn D, Manning AK, Clarke GM, Jung J, Province MA. The Challenge of Detecting Epistasis (GxG Interactions): Genetic Analysis Workshop 16. Genet Epidemiol 2009 Nov;33(S1):S58-S67. 

Young KA, Engelman CD, Langefeld CD, Hairston KG, Haffner SM, Bryer-Ash M, Norris JM.  Association of plasma vitamin D levels with adiposity in Hispanics and African Americans. J Clin Endocrinol Metab 2009 Sep;94(9):3306-13.

Schmitz KJ, Skinner HG, Bautista LE, Fingerlin TE, Langefeld CD, Hicks PJ, Haffner SM, Bryer-Ash M, Wagenknecht LE, Bowden DW, Norris JM, Engelman CD.  Association of 25-hydroxyvitamin D with Blood Pressure in Predominantly 25-hydroxyvitamin D Deficient Hispanic and African Americans. Am J Hypertens 2009 Aug;22(8):367-70.

Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.  J Clin Endocrinol Metab 2008 Sep;93(9):3381-8.

Engelman CD, Brady HL, Baron AE, Norris JM. Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study.  BMC Genetics 2003;4(Suppl 1):S90.

James K, Weitzel L, Engelman CD, Zerbe G, Norris JM. The use of linear mixed models for phenotype identification in a genetic linkage study: genome scan linkage results for longitudinal systolic blood pressure phenotypes in subjects from the Framingham Heart Study.  BMC Genetics 2003;4(Suppl 1):S83.


Courses Taught:

  • PHS 650: Special Topics: Public Health Genomics
  • PHS 904: Special Topics in Epidemiology: Genetic Epidemiology
  • PHS 904: Special Topics in Epidemiology: Analytic Methods in Genetic Epidemiology 

Contact Information:

Address:
1007a WARF Building
610 Walnut Street
Madison, WI 53726

Phone: 608-265-5491
Fax: 608-263-2820
Email: cengelman@wisc.edu

 

Updated On: 
Tue, 07/09/2013
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