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Corinne D Engelman, MSPH, PhD

Research Area: Epidemiology
Keywords: Vitamin D, Genetic Epidemiology, Cognitive Function, Alzheimer’s, Aging


Associate Professor of Population Health Sciences

Email: cengelman@wisc.edu


Biography:

Dr. Engelman is a genetic epidemiologist interested in complex diseases and quantitative traits of aging such as type 2 diabetes, insulin resistance, Alzheimer's disease, cognitive function, and vitamin D deficiency. She is particularly interested in gene-gene and gene-environment interactions and methodologic approaches to studying the genetic contribution to complex phenotypes.

One major area of research is the genetic and non-genetic factors associated with vitamin D. Vitamin D deficiency is associated with many adverse health outcomes, including bone diseases, cancer, autoimmune diseases, infections, diabetes and the metabolic syndrome, hypertension, cardiovascular disease, and cognitive decline, making vitamin D an important health outcome of interest. Dr. Engelman is currently studying the genetic, demographic, behavioral, physiological, and environmental correlates of vitamin D levels in the blood and of the association between vitamin D and other health outcomes, such as blood pressure and lipid concentrations, in Caucasians from the Survey of the Health of Wisconsin (SHOW).

Dr. Engelman is also studying the genetic and non-genetic determinants of cognitive decline in the Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort study of asymptomatic middle-aged adults enriched for a parental history of Alzheimer's disease. She is particularly interested in genes recently reported by genome-wide association studies of Alzheimer's, genes that may be in the physiologic pathway of both Alzheimer's and type 2 diabetes, and vitamin D-related genes. Dr. Engelman is also examining the role of interactions between genes and with non-genetic factors in determining cognitive function and decline.

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Affiliations/Associations:

  • Alzheimer's Disease Research Center, University of Wisconsin
  • American Society of Human Genetics
  • Center for Demography of Health and Aging, University of Wisconsin
  • Genome Center of Wisconsin, University of Wisconsin
  • Institute on Aging, University of Wisconsin
  • International Genetic Epidemiology Society
  • International Society to Advance Alzheimer Research and Treatment

Recent Honors/Awards:

  • Elected member of Delta Omega National Honor Society in Public Health, 2014
  • Population Health Outstanding Instructor Award, 2013
  • Outstanding Young Investigator in Alzheimer's disease, 2012
  • Selected for the AAMC Early Career Women Faculty Professional Development Seminar 2010
  • Teaching Academy Summer Institute Award, 2007
  • Society of Epidemiologic Research Student Workshop Scholarship, 2005
  • University of Alabama at Birmingham Short Course in Statistical Genetics Scholarship, 2003
  • Public Health/Epidemiology Traineeship, 2001

Select Publications:

Sung YJ, Korthauer KD, Swartz MD, Engelman CD.  Methods for collapsing multiple rare variants in whole genome sequence data.  Genet Epidemiol 2014 Aug;38(S1):S13-20.

Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ.  Prediction of genetic contributions to complex traits using whole genome sequencing data.  BMC Proceedings 2014 Jun;8(Suppl 1):S68.

Engelman CD, Bo R, Zuelsdorff M, Steltenpohl H, Kirby T, Nieto FJ.  Epidemiologic study of the C-3 epimer of 25-hydroxyvitamin D3 in a population-based sample.  Clin Nutr 2014 Jun;33(3):421-5. PMCID: PMC3884039

Engelman CD, Koscik RL, Jonaitis EM, Hermann BP, La Rue A, Sager MA.  Investigation of TREM2 variant in the Wisconsin Registry for Alzheimer’s Prevention.  Neurobiology of Aging 2014 Jun;35(6):1252-4.  NIHMSID: NIHMS543150.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Figueroa JD, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA.  Reproductive windows, genetic loci, and breast cancer risk. Ann Epidemiol 2014 May;24(5):376-82.

Bailey EJ, Engelman CD, Walsh MC, Bersch AJ, Martinez-Donate AP, Peppard PE, Nieto FJ, Malecki KC.  Predictors of Discordance Between Perceived and Objective Neighborhood Data. Ann Epidemiol 2014 Mar;24(3):214-21.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA.  Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.  Cancer Epidemiol 2014 Feb;38(1):62-5.

Engelman CD.  Towards personalized prevention of obesity: Can vitamin D negate the FTO effect?  Diabetes 2014 Feb;63(2):405-6.

Meyers KJ, Mares JA, Igo Jr. RP, Truitt B, Liu Z, Millen AE, Klein M, Johnson EJ, Engelman CD, Karki CK, Blodi B, Gehrs K, Tinker L, Wallace R, Robinson J, LeBlanc ES, Sarto G, Bernstein PS, SanGiovanni JP, Iyengar SK.  Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS).  Invest Ophthalmol Vis Sci 2014 Jan 29;55(1):587-99.

Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, La Rue A, Sager MA.  Stressful Events, Social Support, and Cognitive Function in Middle-aged Adults with a Family History of Alzheimer’s Disease.  J Aging Health 2013 Sep;25(6):944-959.  PMCID: PMC3769466

Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA.  Interaction between two cholesterol metabolism genes influences memory: Findings from the Wisconsin Registry for Alzheimer’s Prevention.  J Alzheimers Dis 2013 Aug;36(4):749-757. PMCID: PMC3759032.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Figueroa JD, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA. The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.  Breast Cancer Res Treat 2013 Jul;140(2):427-34.

Meyers KJ, Johnson EJ, Bernstein PS, Iyengar SK, Engelman CD, Karki CK, Liu Z, Igo Jr. RP, Truitt B, Klein M, Snodderly DM, Blodi B, Gehrs K, Sarto G, Wallace R, Robinson J, LeBlanc E, Hageman G, Tinker L, Mares JA.Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study.  Invest Ophthalmol Vis Sci 2013 Mar 28;54(3):2333-2345. PMCID: PMC3626525

Hale L, Hill TD, Friedman E, Nieto FJ, Galvao LW, Engelman CD, Malecki KM, Peppard PE.  Perceived neighborhood quality, sleep quality, and health status: Evidence from the Survey of the Health of Wisconsin.  Soc Sci Med 2013 Feb;79:16-22.  PMCID: PMC3733364.

 

Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo, Jr RP, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE.  Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations. J Nutr 2013 Jan;143(1):17-26.  PMCID: PMC3521459.

 

Ghosh S, Bickeböller H, Bailey J, Bailey-Wilson JE, Cantor R, Culverhouse R, Daw W, Destefano AL, Engelman CD, Hinrichs A, Houwing-Duistermaat J, König IR, Kent J Jr, Laird N, Pankratz N, Paterson A, Pugh E, Suarez B, Sun Y, Thomas A, Tintle N, Zhu X, Ziegler A, Maccluer JW, Almasy L.  Identifying rare variants from exome scans: the GAW17 experience.  BMC Proceedings 2011 Nov; 5(S9):S1:1-4.  PMCID: PMC3287821

 

Bueno Filho JS, Morota G, Tran QT, Maenner MJ, Vera-Cala LM, Engelman CD, Meyers KJ.  Analysis of human mini-exome sequencing data using a Bayesian hierarchical mixture model: Genetic Analysis Workshop 17.  BMC Proceedings 2011 Nov;5(S9):S93:1-8. PMCID: PMC3287935

 

Ye KQ and Engelman CD.  Detecting Multiple Causal Rare Variants in Exome Sequence Data. Genet Epidemiol 2011 Nov;35(S1):S18-21. PMCID: PMC3271433

 

Engelman CD.  Vitamin D recommendations: the saga continues.  J Clin Endocrinol Metab 2011 Oct;96(10):3065-6.

Kluczynski MA, LaMonte MJ, Mares JA, Wactawski-Wende J, Smith AW, Engelman CD, Andrews CA, Snetselaar LG, Sarto GE, Millen AE.  Duration of Physical Activity and Serum 25-hydroxyvitamin D Status of Postmenopausal Women.  Ann Epidemiol 2011 Jun;21(6):440-449. PMCID: PMC3090482

 

Nieto FJ, Peppard PE, Engelman CD, McElroy JA, Galvao LW, Friedman EM, Bersch AJ, Malecki KC.  The Survey of the Health of Wisconsin (SHOW), a novel infrastructure for population health research: rationale and methods.  BMC Public Health 2010 Dec;10:785. PMCID: PMC3022857

 

Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Rotter JI, Bowden DW, Langefeld CD, Norris JM.  Genome-wide association study of vitamin D concentrations in Hispanic Americans: The IRAS Family Study.  J Steroid Biochem Mol Biol 2010 Oct;122(4):186-92. PMCID: PMC2949505

 

Bendlin BB, Carlsson CM, Gleason CE, Johnson SC, Sodhi A, Gallagher CL, Puglielli L, Engelman CD, Ries ML, Xu G, Wharton W, Asthana S.  Midlife predictors of Alzheimer’s disease.  Maturitas 2010 Feb;65(2):131-7.  PMCID: PMC2895971

 

Maenner MJ, Denlinger LC, Langton A, Meyers KJ, Engelman CD, Skinner HG.  Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests.  BMC Proceedings 2009 Dec;3(S7):S88:1-5.  PMCID: PMC2795991

 

Yao L, Zhong W, Zhang Z, Maenner MJ, Engelman CD.  Classification tree for selection of single-nucleotide polymorphism (SNP)-by-SNP interactions related to heart disease: Framingham Heart Study.  BMC Proceedings 2009 Dec;3(S7):S83:1-6.  PMCID: PMC2795986

 

González-Recio O, López de Maturana E, Vega AT, Engelman CD, Broman KW.  Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model.  BMC Proceedings 2009 Dec;3(S7):S63:1-5.  PMCID: PMC2795964  

 

Shim H, Chun H, Engelman CD, Payseur BA.  Genome-wide association studies using single-nucleotide polymorphisms versus haplotypes: an empirical comparison with data from the North American Rheumatoid Arthritis Consortium.  BMC Proceedings 2009 Dec;3(S7):S35:1-6.  PMCID: PMC2795933

 

Engelman CD, Baurley JW, Chiu YF, Joubert BR, Maenner MJ, Murcray CE, Shi G, Gauderman, WJ.  Detecting Gene-Environment Interactions in Genome-Wide Association Data.  Genet Epidemiol 2009 Nov;33(S1):S68-73.  PMCID: PMC2924567

 

An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang C, Zheng T, Kovac IP, Dubé M, Liang X, Li J, Andrade M, Culverhouse R, Malzahn D, Manning AK, Clarke GM, Jung J, Province MA.  The Challenge of Detecting Epistasis (GxG Interactions):  Genetic Analysis Workshop 16.  Genet Epidemiol 2009 Nov;33(S1):S58-67. PMCID: PMC3692280

 

Young KA, Engelman CD, Langefeld CD, Hairston KG, Haffner SM, Bryer-Ash M, Norris JM.  Association of plasma vitamin D levels with adiposity in Hispanics and African Americans.  J Clin Endocrinol Metab 2009 Sep;94(9):3306-13.  PMCID: PMC2741711

 

Schmitz KJ, Skinner HG, Bautista LE, Fingerlin TE, Langefeld CD, Hicks PJ, Haffner SM, Bryer-Ash M, Wagenknecht LE, Bowden DW, Norris JM, Engelman CD.  Association of 25-hydroxyvitamin D with Blood Pressure in Predominantly 25-hydroxyvitamin D Deficient Hispanic and African Americans.  Am J Hypertens 2009 Aug;22(8):367-70.  PMCID: PMC2865679

 

Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM.  Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.  J Clin Endocrinol Metab 2008 Sep;93(9):3381-8.  PMCID: PMC2567851

 

Engelman CD, Brady HL, Baron AE, Norris JM.  Comparison between two analytic strategies to detect linkage to obesity with genetically determined age of onset: the Framingham Heart Study.  BMC Genetics 2003;4(S1):S90:1-5.  PMCID: PMC1866531

 

James K, Weitzel L, Engelman CD, Zerbe G, Norris JM.  Genome scan linkage results for longitudinal systolic blood pressure phenotypes in subjects from the Framingham Heart Study.  BMC Genetics 2003;4(S1):S83:1-5.  PMCID: PMC1866523

 


Courses Taught:

  • PHS 650: Special Topics: Public Health Genomics
  • PHS 904: Special Topics in Epidemiology: Genetic Epidemiology
  • PHS 904: Special Topics in Epidemiology: Analytic Methods in Genetic Epidemiology 

Contact Information:

Address:
1007a WARF Building
610 Walnut Street
Madison, WI 53726

Phone: 608-265-5491
Fax: 608-263-2820
Email:
cengelman@wisc.edu

 

Updated On: 
Sat, 07/19/2014
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